Work

Solid State Synthesis of Hyaluronic Acid–Quercetin Conjugate: Sustainable Protocol to Improve the Biological Activity of Quercetin

Year: 2024

Type: article

Abstract: Herein, a sustainable solid-state procedure is employed for the synthesis of a water-soluble molecule obtained by linking hyaluronic acid to the hydrophobic quercetin (HA-QCT). The micellar self-aggregation of the developed conjugate suggested its employment as a drug delivery nano-system, considering the numerous biological activities of QCT. Indeed, the spectroscopic characterization (ultraviolet-visible and Fourier transform infrared) ensured that the QCT maintained its chemical integrity. In addition, a cytotoxicity test revealed that HA-QCT can be employed as a biocompatible drug vehicle for pharmacological purposes. A preliminary colorimetric test also confirmed that QCT retained its anti-oxidant activity.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202402495

Authors: Valentina Verdoliva, Giuliana Muzio, Riccardo Autelli, Stefania De Luca

Institutions: National Research Council, Institute of Crystallography, University of Turin, Institute of Biostructure and Bioimaging

Language: English

Topic: Hydrogels: synthesis, properties, applications

Subfield: Molecular Medicine

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,700