Work

Enantioselective nickel-catalyzed electrochemical reductive conjugate alkenylation of α,β-unsaturated ketones

Year: 2024

Type: article

Abstract: Catalytic electrochemical asymmetric catalysis is emerging as a promising strategy for the synthesis of chiral compounds. Herein, we report an asymmetric electrochemical nickel-catalysed reductive conjugate addition of alkenyl bromides/aryl iodides to α,β-unsaturated ketones in an undivided cell, leading to addition products with high yields and excellent enantioselectivities (up to 96% yield and 96% ee).

Source: Chemical Science

DOI: 10.1039/d4sc06891b

Authors: Siriphong Somprasong, Bin Wan, Syuzanna R. Harutyunyan

Institution: University of Groningen

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funders: China Scholarship Council, European Research Council, H2020 European Research Council

Awards: G1678412988, Lewis acid promoted copper catalysis to functionalise and dearomatise arenes