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Associations between human milk EV-miRNAs and oligosaccharide concentrations in human milk

Year: 2024
Type: article
Study design: Observational Study
Abstract: Introduction: Human milk contains human milk oligosaccharides (HMOs) and microRNAs (miRNAs), which are key bioactive components. HMOs are indigestible carbohydrates that impact infant growth and development. miRNAs are small, non-coding RNAs that regulate post-transcriptional gene expression. miRNAs are abundant in human milk and can be contained in extracellular vesicles (EVs). There is evidence that miRNAs are synthesized in the mammary epithelium and may influence mammary gland development and milk synthesis. However, the relationships between miRNAs and HMOs have yet to be fully characterized. Methods: This study examined the associations between 210 human milk EV-miRNAs and 19 HMOs in a cohort of 98 Latina mothers. HMO measures included summary measures and concentrations of 19 HMOs. Relationships between EV-miRNAs and HMOs were examined using principal components analysis and associations between individual EV-miRNAs and HMOs were assessed. Results: Overall patterns of EV-miRNA levels, summarized using principal components, were associated with HMO summary measures and concentrations. Levels of individual EV-miRNAs were associated with HMO summary measures and individual concentrations of 2'FL, 3FL, 3'SL, 6'SL, FLNH, LNFP I, and LNH. Discussion: Results from this study suggest that human milk EV-miRNAs are associated with the concentration of HMOs, which may have important effects on infant growth and development.
DOI: 10.3389/fimmu.2024.1463463
Authors: Elizabeth A. Holzhausen, William B. Patterson, Benjamin H. Wong, Sewan Kim, Allison Kupsco, Caitlin G. Howe, Lars Bode, Michael I. Goran, Tanya L. Alderete
Institutions: Johns Hopkins University, University of Colorado Boulder, University of Colorado Anschutz, Columbia University, Dartmouth College, University of California San Diego, Children's Hospital of Los Angeles
Language: English
Field: Nursing
Open Access status: gold
Estimated APC paid: $3,295
Funders: National Institutes of Health, University of California, San Diego, National Heart, Lung, and Blood Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Environmental Health Sciences, National Institute on Minority Health and Health Disparities
Awards: G1988778843, G2658428538, G272782595, G6794595371, G804905152, G89476839, G9000116392, Transdisciplinary Training in Sleep and Circadian Research, Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children
OpenAlex ID: W4404551644
FWCI: 0.686
Cites: 65
Cited by: 3
Related to: 10