Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Atopic dermatitis (AD) might delay puberty, but research is lacking. Objective: To investigate the association between AD and puberty. Methods: A subcohort within the Danish National Birth Cohort includes children born between 2000 and 2003, with mothers reporting doctor-diagnosed AD at 6 months, 18 months, and 7 years old. The National Patient Registry identified hospital-diagnosed AD. From 11 years, the children give half-yearly information on pubertal development. We estimated the mean age difference in months at attaining Tanner stages 1 to 5 and the development of axillary hair, acne, first ejaculation, voice break, and age at menarche, using an interval-censored regression model. Results: In total, 15,534 children participated, 21.5% had self-reported doctor-diagnosed AD and 0.7% had hospital-diagnosed AD. For girls with self-reported doctor-diagnosed AD, the average age difference at reaching all pubertal milestones was 0.0 months (95% confidence interval [CI]: -0.8; 0.8), and for hospital-diagnosed AD, it was -0.3 months (95% CI: -5.4; 4.8). For boys, the average age difference was 0.1 months (95% CI: -0.6; 0.9) and -0.3 months (95% CI: -3.6; 3.0), respectively. Limitations: No information on treatment was available. Missing data on covariates (<5%) were not addressed. Conclusion: No association was found between AD and puberty in either girls or boys.
Source: JAAD International
Language: English
Subfield: Dermatology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,575
Funders: March of Dimes Foundation, Aarhus Universitet, Sundhed og Sygdom, Det Frie Forskningsråd, Innovationsfonden, Health Foundation, European Commission, National Research Foundation, Danmarks Grundforskningsfond, Københavns Universitet, Lundbeckfonden, Nordea-fonden, Danmarks Frie Forskningsfond, Egmont Fonden, H. Lundbeck A/S, Medical Research Council, European Research Council, Statens Serum Institut, H2020 European Research Council
Awards: G1031846133, G1293115906, G1615615194, G1749882372, G186520367, G1936523031, G2073588333, G2131399289, G2145814837, G2193368973, G2384235469, G2642389388, G2954833423, G3233039117, G3276785593, G3342218268, G3811067617, G3814547547, G4117695673, G4248035517, G425496590, G4918890226, G5369471226, G5378249968, G5692678496, G5702547812, G5849383024, G5979485127, G6176336860, G6416074183, G6420165006, G6947076504, G7088383309, G7228047770, G7617179328
OpenAlex ID: W4404552809