Work

Effect of maternal beta-blocker treatment on mean fetal heart rate

Year: 2024

Type: article

Abstract: Background: During pregnancy, the prescription of beta-blockers to the mother may be necessary for pre-existing chronic conditions. Their use raises concerns due to potential effects on the fetus. Objectives: This study aimed to investigate the impact of beta-blockers on mean fetal heart rate in pregnant women treated with these medications compared to an untreated patient group. Study Design: This was a retrospective case-control study involving 90 patients, divided into two groups: 45 patients on beta-blockers and 45 untreated patients. Included patients delivered singleton pregnancies after 24 weeks of gestational age at two university hospitals in Île-de-France between 2009 and 2021. They were matched based on age, parity, and gestational age at delivery. Fetal heart rate and maternal heart rate were recorded on the day of delivery. Pregnancy outcomes were studied secondarily. Results: =.71). Among patients taking beta-blockers, the most commonly used treatment was bisoprolol. Conclusion: The study did not reveal a significant effect of beta-blockers on fetal heart rate. However, close monitoring and appropriate clinical management are still necessary for pregnant patients on beta-blocker treatment due to other potential implications like intra-uterine growth restriction for both the mother and the fetus.

Source: AJOG Global Reports

DOI: 10.1016/j.xagr.2024.100423

Authors: Sarah Hautier, Thi Minh Thu Nguyen, Arane Kim, Tiphaine Barral, Dominique Luton

Institutions: Université Paris-Saclay, Assistance Publique – Hôpitaux de Paris, Bicêtre Hospital, Hôpital Bichat-Claude-Bernard, Hôpital Pellegrin

Language: English

Topic: Pregnancy and Medication Impact

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800