Development and characterization of a low intensity vibrational system for microgravity studies
Year: 2024
Type: article
Abstract: The advent of extended-duration human spaceflight demands a better comprehension of the physiological impacts of microgravity. One primary concern is the adverse impact on the musculoskeletal system, including muscle atrophy and bone density reduction. Ground-based microgravity simulations have provided insights, with vibrational bioreactors emerging as potential mitigators of these negative effects. Despite the potential they have, the adaptation of vibrational bioreactors for space remains unfulfilled, resulting in a significant gap in microgravity research. This paper introduces the first automated low-intensity vibrational (LIV) bioreactor designed specifically for the International Space Station (ISS) environment. Our research covers the bioreactor's design and characterization, the selection of an optimal linear guide for consistent 1-axis acceleration, a thorough analysis of its thermal and diffusion dynamics, and the pioneering use of BioMed Clear resin for enhanced scaffold design. This advancement sets the stage for more authentic space-based biological studies, vital for ensuring the safety of future space explorations.
Source: npj Microgravity
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,390
Awards: Center of Biomedical Research Excellence in Matrix Biology Phase II, G1062220900, G2732365621, RII Track-4: Mechanical Regulation of Intra-Nuclear Mechanics and Gene Transcription, ISS/Collaborative Research: 3D Bone Marrow Analogs to Determine the Contribution of Mechanical Signals to Aging MSC Function in Microgravity, G4844227136, G617094578, Live Cell Imaging System for Biomechanics and Mechanobiology Research, G7183489566, G9000240388, Idaho INBRE Program, Convergent Engineering and Biomolecular Science, G919360398
OpenAlex ID: W4404566673