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A case report of verapamil toxicity leading to haemodynamic compromise in obstructive hypertrophic cardiomyopathy

Year: 2024

Type: article

Abstract: Background: Hypertrophic cardiomyopathy (HCM) is an inherited condition characterized by left ventricular (LV) hypertrophy unexplained by increased afterload, often with concomitant outflow tract obstruction. Verapamil is commonly used to treat symptomatic patients. However, its potential for adverse effects should be recognized. Case summary: This report provides a case of cardiogenic shock in HCM, where a patient presented with chief complaint of fatigue and shortness of breath with an acute decline in LV systolic function on echocardiogram. His symptoms were attributed to verapamil toxicity following a recent increase in dosage. He achieved rapid symptom relief after holding his home medications, in addition to conservative management. Discussion: This case report aims to elucidate the potential for multiple adverse effects involved with verapamil use in patients with obstructive HCM.

Source: European Heart Journal - Case Reports

DOI: 10.1093/ehjcr/ytae596

Authors: Jonathan W Gau, Florian Rader, Behram Mody, Andy Y Lee

Institutions: University of California, Irvine, Cedars-Sinai Medical Center, Cedars-Sinai Smidt Heart Institute

Language: English

Topic: Cardiomyopathy and Myosin Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $819