Work

The impact of diet-induced obesity on 5 fluorouracil-induced tumor and liver immune cell cytotoxicity

Year: 2024

Type: article

Abstract: The current study aimed to examine the impact of obesity on tumorigenesis and 5FU safety and efficacy with two established murine models of colorectal cancer. Diet-induced obesity increased tumor burden in both models, and 5FU's antitumor efficacy remained and extended survival with both tumor models. Obese mice demonstrated increased 5FU-induced immune cell cytotoxicity following multiple cycles of 5FU with distinct changes to liver macrophages, suggesting an increased propensity for liver metastasis.

Source: American Journal of Physiology-Cell Physiology

DOI: 10.1152/ajpcell.00687.2024

Authors: Brandon N. VanderVeen, Thomas D. Cardaci, Brooke M. Bullard, Christian A. Unger, Jeffrey C. Freeman, Reilly T. Enos, Michael Shtutman, Michael D. Wyatt, Daping Fan, E. Angela Murphy

Institution: University of South Carolina

Language: English

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences

Awards: BD FACSymphony A5 Cell Analyzer, G2530004522, G2764684304, G4279400976, G6493845342, G7646779522, A Transdisciplinary Approach to Investigating Metabolic Dysregulation in Obese Parent and Child Dyads and Risk of Colorectal Cancer, B-cell-intrinsic MHCII Signaling is a Diversifying Force of Selection on IgA Repertoires and the Gut Microbiota

OpenAlex ID: W4404572936

FWCI: 0.408

Cites: 56

Cited by: 3

Related to: 10