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Taxifolin Antihypertensive Effect in an Age-Related Hypertension Model

Year: 2024
Type: article
Abstract: This work shows that age-related arterial hypertension in Wistar rats develops with age, in 52% of 18-monthold animals versus 33% of 3-month-old animals. Effects of Taxifolin at a dose of 100 mg/kg, administered intraperitoneally for a week, on blood pressure (BP) and biochemical parameters in 18-month-old and 3-month-old animals were studied. The experimental animals were divided into two groups, those normotensive (BP<115 mmHg) and hypertensive (BP>115 mmHg). It was shown that a weekly course of Taxifolin leads to a significant decrease in blood pressure in hypertensive 18-month-old animals with no effect on blood pressure in normotensive animals. In addition, some age-related changes in the biochemical parameters of blood under the influence of Taxifolin were revealed.
DOI: 10.33647/2713-0428-20-3e-206-210
Authors: N. A. Perepechenova, E. A. Tukhovskaya, A. M. Ismailova, E. R. Shayhutdinova, G. A. Slashcheva, E. S. Sadovnikova, I. A. Dyachenko, A. N. Murashev
Language: English
Field: Medicine
Open Access status: diamond
OpenAlex ID: W4404578034
FWCI:
Cites: 3
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Related to: 10