Studying the Hypoglycemic Activity of Combinations of Maloben with Synthetic Antidiabetic Drugs on a Streptozocin Model of Diabetes Mellitus
Year: 2024
Type: article
Abstract: In this paper, we study the hypoglycemic activity of the 4,4'-(propanediamido)dibenzoate sodium (maloben) pharmaceutical substance in combination with metformin, an antidiabetic drug of the biguanide class, and empagliflozin, an inhibitor of sodium-dependent glucose transporter type 2 (SGLT2) in the kidneys, in the setting of a streptozocin model of diabetes mellitus in combination with a high-fat diet in laboratory outbred male rats. The use of a high-fat diet makes it possible to simulate the state of prediabetes and increase the effectiveness of streptozocin administration. Streptozocin increases the level of glucose in the blood and urine of animals, as well as that of diuresis, which indicates the development of a pathology similar to actual type 2 diabetes mellitus. As part of the study, the dynamics of changes in glucose in the blood and urine, daily diuresis, and body weight of animals were analyzed.
Source: Journal Biomed
Authors: N. A. Anisimova, A. O. Ezhova
Institution: Ministry of Health of the Russian Federation
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404578065