Work

Immunization of Lambs with Recombinant Myostatin Affects Growth Rates

Year: 2024

Type: article

Abstract: Immuno-biotechnological methods for increasing the meat productivity of farm animals may be in demand for effective animal husbandry. Currently, recombinant proteins and peptides are increasingly used as antigens for immunization purposes. Previously, we obtained a strain-producer of recombinant myostatin. The protein was developed, purified under denaturing conditions and, in a composition with aluminum hydroxide gel, rMST was used as a vaccine for immunization of four-month-old lambs. The effect of the vaccine administration method on the live weight gain of lambs was investigated. It was shown that onetime subcutaneous multipoint immunization of four-month-old lambs with rMST at a dosage of 1 mg/head in aluminum hydroxide gel as an adjuvant was more effective than intramuscular vaccination in stimulating body weight gain.

Source: Journal Biomed

DOI: 10.33647/2713-0428-20-3e-54-58

Authors: O. B. Zhukova, E. M. Koloskova

Institution: Federal Scientific Center for Animal Husbandry named after Academician L.K. Ernst

Language: English

Topic: Pharmacological Effects and Assays

Subfield: Animal Science and Zoology

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDGs: Zero hunger, Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404578075

FWCI: 0.774

Cites: 9

Cited by: 3

Related to: 10