Work

Increasing the water solubility of N-acyl-substituted amino acid esters as inhibitors of the replication of modern influenza A virus strains in vitro due to zinc(II) complexation

Year: 2024

Type: article

Abstract: This article proposes carbocyclic derivatives of N-acylated esters of L-amino acids with aromatic carboxylic acids as antiviral low-molecular agents. To increase the water solubility of inhibitors that are insoluble in aqueous solutions, the target compounds were used in the form of zinc(II) complexes. It has been shown that hydrophobic organic compounds in the form of zinc(II)-coordinated ligands are capable of suppressing the replication of an influenza A virus strain resistant to adamantane-type drugs. Zinc(II) chloride at the concentration used does not have antiviral or toxic effects in experiments in vitro.

Source: Журнал неорганической химии

DOI: 10.31857/s0044457x24050113

Authors: Т. М. Garaev, I. I. Yudin, N. V. Breslav, Т. Е. Savochkina, А. S. Krepkaya, Т. V. Grebennikova, S. Е. Nikiforova, I. I. Myshletsov, V. V. Avdeeva, Е. А. Malinina

Institutions: Ministry of Health of the Russian Federation, Russian Academy of Sciences, NS Kurnakova Institute of General and Inorganic Chemistry

Language: English

Topic: Influenza Virus Research Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

Open Access status: diamond

OpenAlex ID: W4404578666

FWCI:

Cites: 22

Cited by:

Related to: 10