Work

Immune complex deposition promotes NK cell accumulation in the kidney

Year: 2024

Type: article

Abstract: In systemic lupus erythematosus, immune complexes deposited in the kidney vasculature represent a potent inflammatory trigger with a high potential to progress to glomerulonephritis and organ failure. These immune complexes can be recognized by multiple effector cells via complement and Fcγ receptors. The transcriptome of CD16-bearing NK cells has been documented in kidneys from patients with SLE. In this study, we show that NK cells accumulate in the kidney in response to immune complex deposition and modulate the behavior of local T cells. Depletion of NK cells transiently ameliorated disease, suggesting NK cells may play a role in lupus nephritis and other immune complex-mediated conditions.

Source: PLoS ONE

DOI: 10.1371/journal.pone.0312141

Authors: Abigail De la Cruz, Marco Garcés, Emiliano Larios, Iris K. Madera-Salcedo, José C. Crispín, Florencia Rosetti

Institutions: Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Universidad Nacional Autónoma de México, Secretaria de Salud, Tecnológico de Monterrey

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,290