Atrophy Patterns in Patients With Multiple Sclerosis With Cognitive Impairment, Fatigue, and Mood Disorders
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND OBJECTIVES: Cognitive impairment, fatigue, and mood disorders are common in multiple sclerosis (MS), but their interplay and neurologic substrates are not well understood. This study aims to identify atrophy patterns in patients with MS with varying levels of cognitive impairment, fatigue, anxiety, and depression. METHODS: -score <-1.5, with intergroup comparisons using Bayesian multinomial logistic regression (95% CI). RESULTS: < 0.001), compared with K1. DISCUSSION: Cognitive impairment, fatigue, anxiety, and depression in patients with MS can coexist or present independently. Our findings suggest a stronger association between cognitive impairment and deep gray matter atrophy while fatigue, anxiety, and depression are more strongly associated with cerebellar atrophy. The accumulation of cognitive impairment, fatigue, anxiety, and depression is associated with increasing global cortical and deep gray matter atrophy.
Source: Neurology
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Biogen, Teva Pharmaceutical Industries, Celgene, Fondation pour l'Aide à la Recherche sur la Sclérose en Plaques, European Committee for Treatment and Research in Multiple Sclerosis, Prothena, Atara Biotherapeutics, National Institute for Health and Care Research, Fundação de Amparo à Pesquisa do Estado de São Paulo, ZonMw, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Eisai, Multiple Sclerosis International Federation, University College London Hospitals NHS Foundation Trust, IXICO, MedDay Pharmaceuticals, Amsterdam Neuroscience, Eurostars
OpenAlex ID: W4404582600