New PKS/NRPS Tenuazamines A–H from the Endophytic Fungus Alternaria alternata FL7 Isolated from Huperzia serrata
Year: 2024
Type: article
Abstract: In this paper, we present a novel class of hybrid polyketides, tenuazamines A–H (1–8), which exhibit a unique tautomeric equilibrium from Alternaria alternata FL7. The elucidation of the structures was achieved through a diverse combination of NMR, HR-ESIMS, and ECD methods, with a focus on extensive spectroscopic data analysis. Notably, compounds 1, 4, 8–9 exhibited potent toxic effects on the growth of Arabidopsis thaliana. This research expands the structural diversity of tenuazonic acid compounds derived from endophytic fungi and provides potential hit compounds for the development of herbicides.
Source: Journal of Fungi
DOI: 10.3390/jof10120809
Authors: Hao Zhang, Zhibin Zhang, Yiwen Xiao, Wen Wang, Boliang Gao, Yuhao Xie, Jiahao Xie, Xinhua Gao, Du Zhu
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,955
OpenAlex ID: W4404586198