Work

Olorofim demonstrates in vitro activity against Coccidioides species, including isolates against which fluconazole has reduced activity

Year: 2024

Type: article

Abstract: ABSTRACT We evaluated the in vitro activity of olorofim against Coccidioides species. Olorofim demonstrated potent in vitro activity against all isolates tested with a minimum inhibitory concentration (MIC) range ≤0.008–0.06 µg/mL and geometric mean MIC of 0.010 µg/mL. This activity was also maintained against isolates with elevated fluconazole MICs (≥16 µg/mL), including strains with MICs ≥32 µg/mL (olorofim MIC range ≤0.008–0.06 µg/mL and geometric mean MICs of ≤0.009 and ≤0.013 µg/mL, respectively).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00988-24

Authors: Nathan P. Wiederhold, Hoja P. Patterson, Dora Ferrer, Victor Garcia, George R. Thompson, Thomas F. Patterson

Institutions: The University of Texas at San Antonio Health Science Center, University of California, Davis

Language: English

Topic: Fungal Infections and Studies

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid