Work

Thermal CO Release Reactivity of a π-Extended Flavonol Anion

Year: 2024

Type: article

Abstract: The π-extended flavonol Flav-1 ( 1 ) undergoes reaction with KOH or KO 2 to form 1 –, which reacts with O 2 at ambient temperature, resulting in CO release and depside formation. Mechanistic and DFT studies support a reaction pathway involving reaction of 1 – with O 2 on the triplet energy surface in the rate-determining step. Formation of a cyclic peroxide leads to CO extrusion. These studies indicate that if formed in biological environments, 1 – will release CO in the absence of light illumination.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03651

Authors: Stephen N. Anderson, C. Taylor Dederich, Tomasz Borowski, Lisa M. Berreau

Institutions: Utah State University, Jerzy Haber Institute of Catalysis and Surface Chemistry, Polish Academy of Sciences

Language: English

Topic: Molecular Sensors and Ion Detection

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: Infrastruktura PL-Grid, National Institutes of Health, Academic Computer Centre Cyfronet, AGH University of Science and Technology, National Institute of General Medical Sciences

Awards: G2033918870, G9000346082