Work

Purine nucleosides as selective inhibitors of butyrylcholinesterase – a multidisciplinary study

Year: 2024

Type: article

Abstract: A multidisciplinary study of purine nucleoside selective BuChE inhibitors, covering docking, synthesis, biological evaluation and cytotoxic assays.

Source: Organic & Biomolecular Chemistry

DOI: 10.1039/d4ob01657b

Authors: Vasco Cachatra, Alice Martins, Maria Conceição Oliveira, Maria Cristina Oliveira, Lurdes Gano, António Paulo, Óscar López, José G. Fernández-Bolaños, Marialessandra Contino, Nicola Antonio Colabufo, David Evans, Teresa Man, Amélia Pilar Rauter

Institutions: University of Lisbon, Centro de Química Estrutural, Universidade de Leiria e Oeste, Instituto Superior Técnico, Centro de Ciências e Tecnologias Nucleares, Universidad de Sevilla, University of Bari Aldo Moro, Eli Lilly (United Kingdom)

Language: English

Topic: Cholinesterase and Neurodegenerative Diseases

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funders: Ministerio de Ciencia, Innovación y Universidades, Fundação para a Ciência e a Tecnologia, FP7 People: Marie-Curie Actions

Awards: NEW SYNTHETIC STRATEGIES AND STRUCTURAL OPTIMIZATION OF THE SUGAR MOIETY FROM A SELECTIVE BUTYRYLCHOLINESTERASE INHIBITOR, Centro de Química Estrutural, Instituto de Ciências Moleculares, Centro de Ciências do Mar e do Ambiente, G5827399791, G624877701, G729554784, Centro de Química Estrutural, Centro de Ciências do Mar e do Ambiente

OpenAlex ID: W4404590776

FWCI: 0.477

Cites: 37

Cited by: 2

Related to: 10