Effect of infusion time on risk of Bacillus cereus bloodstream infections in patients administered with BFLUID amino acid infusions via peripheral venous catheters
Year: 2024
Type: article
Study design: Observational Study
Abstract: Comprehensive electrolyte infusions containing amino acids, including BFLUID, are a source of nosocomial infections caused by Bacillus cereus. It is recommended that clinicians finish the administration of BFLUID within 6 h; however, this recommendation currently lacks supporting empirical evidence. Accordingly, the present study aimed to investigate the risk of B. cereus infection associated with BFLUID infusion according to the administration time. In the present single‑center retrospective observational cohort study, clinical information was extracted from the medical records of patients aged ≥18 years who received BFLUID infusions via a peripheral line between April 2017 and October 2020 at Saitama Red Cross Hospital (Saitama, Japan). A total of 96 patients were enrolled during the study period, of whom 32 developed B. cereus infection. No patients with BFLUID infusions administered within 6 h developed B. cereus infection. Compared with patients who received BFLUID infusions within 8 h, those who received BFLUID infusions after 8 h had a 7‑fold higher risk of infection. The present study provided empirical evidence supporting the recommendation that amino acid infusions should be administered to patients within 6 h to minimize the risk of B. cereus infection.
Source: Biomedical Reports
DOI: 10.3892/br.2024.1895
Authors: Atsushi Takano, Yuta Nakamaru, Ken-Ichi Sako, Asuka Takano, Masanori Iga, Mitsuru Machida, Teppei Kaku, Atsushi Ishimura, Hirotaka Nakasuga, Yoshikazu Matsuda, Yoshio Fujikake, Tomoji Maeda
Institutions: Saitama Red Cross Hospital, Nihon Pharmaceutical University
Language: English
Subfield: Emergency Medical Services
Field: Health Professions
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404592182