Work

Combination treatment with photodynamic therapy and antibiotic in refractory cutaneous nocardiosis: A case report

Year: 2024

Type: article

Abstract: • We describes a case of cutaneous nocardiosis infected by N.brasiliensis who was effectively treated in a brief amount of time utilizing ALA-PDT in conjunction with antibiotics, while using antibiotics alone had no therapeutic effect. • This report underscores the efficacy of ALA-PDT to N.brasiliensis infection, which can shorten the duration of treatment and enhance the antibiotics sensitivity of pathogenic bacteria. ALA-PDT can be a new method to treat N.brasiliensis infection, especially when the antibiotics can not achieve significant efficacy. Effective management of cutaneous nocardiosis is hampered by the lack of defined treatment recommendations and frequently requires prolonged antibiotic therapy. This report describes a case of cutaneous nocardiosis who was effectively treated in a brief amount of time with three sessions of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) in conjunction with antibiotics. ALA-PDT combined with antibiotics may effectively treat refractory cutaneous nocardiosis.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2024.104414