Work

Neuroprotection and activation of anti-inflammatory and plasticity mechanisms by PLC-β inhibition after cholinergic hyperstimulation in hippocampal slices and microglial cells

Year: 2024

Type: article

Abstract: ) implicated in epilepsy. Notably, these effects were observed without compromising cell viability. Our findings propose PLC-β inhibition as a promising therapeutic strategy against seizures, with Ef emerging as a potential non-classical treatment option.

Source: IBRO Neuroscience Reports

DOI: 10.1016/j.ibneur.2024.11.011

Authors: Daraishka Pérez-Caraballo, Grace Torres, Sthephanie Estrada, Yaritza Inostroza-Nieves, Dinely Pérez, Pedro Ferchmin, Yamixa Delgado, Yancy Ferrer-Acosta

Institutions: Central University of the Caribbean, San Juan Bautista School of Medicine, University of Puerto Rico at Cayey, University of Puerto Rico at Río Piedras, University of Puerto Rico, Medical Sciences Campus, University of Puerto Rico System

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,500

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities

Awards: G1832691432, G3060255352, G4626340976, G4952206072, G64558799, Hispanic Alliance for Clinical and Translational Research (Alliance), Puerto Rico Clinical and Translational Research Consortium (PRCTRC), Advancing Competitive Biomedical Research in Puerto Rico, Center for Collaborative Research in Health Disparities

OpenAlex ID: W4404592489

FWCI: 0.268

Cites: 91

Cited by: 1

Related to: 10