Work

Etiology and Clinical Profile of Pediatric Acquired Demyelination Syndromes of the Central Nervous System: An Ambispective Longitudinal Study from South India

Year: 2024

Type: article

Abstract: Background Pediatric acquired demyelinating disorders (pADS) are diverse disorders with varied clinical presentations and literature regarding them is far and few. Materials and methods This ambispective study included 46 children with pADS who presented between 2016 and 2021 to our institution. Results The most common form was acute demyelinating encephalomyelitis (ADEM) (41.3%). The most common symptom was limb weakness (45.6%). During follow-up, regression of milestones was observed in 3(7.5%) children, and seizures were seen in 4(10%) children. Except for two children, all others could perform activities of daily living. Residual weakness was seen in six children. Recurrence of pADS was seen in five children. Conclusion ADEM was the most common pADS, and 20% had residual deficits. Though mortality is rare in these groups of conditions, morbidity is significantly high, which can be reduced with proper and early treatment with immunosuppressants.

Source: Indian journal of clinical medicine

DOI: 10.1177/26339447241297011

Authors: Kiruthiga Sugumar, Aakash Chandran Chidambaram, Jaikumar Govindaswamy Ramamoorthy

Institution: Jawaharlal Institute of Post Graduate Medical Education and Research

Language: English

Topic: Multiple Sclerosis Research Studies

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,200