Year: 2024
Type: article
Abstract: In the present study, Pušnik et al. investigated whether the XBB.1.5-adapted booster can overcome the persistent imprinting of SARS-CoV-2 immunity by wild-type based vaccines. The findings demonstrate increased plasma neutralization against the homologous variant following the booster vaccination. Formation of de novo humoral response against the mutated epitopes of XBB.1.5 variant's surface proteins was observed in 3/20 individuals. The booster vaccination had no significant effect on T-cell response.
Source: npj Vaccines
Authors: Jernej Pušnik, Werner O. Monzon-Posadas, Emmanuil Osypchuk, Aleksandra Elzbieta Dubiel, Maximilian Baum, Paulina Fehring, Antonia Büning, Tobias Klant, Hendrik Streeck
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,690
OpenAlex ID: W4404593978