Work

Stereoselective Total Synthesis of Natural Decanolides Bellidisin C and Pinolidoxin

Year: 2024

Type: article

Abstract: A divergent total synthesis of bioactive, naturally occurring decanolides, pinolidoxin and bellidisin C, was accomplished by taking advantage of chiral templates L-ribose and L-malic acid. In particular, bellidisin C, which is the first total synthesis so far, was achieved through a cascade reaction of reductive elimination and nucleophilic addition in a one-pot process and a sodium–alkoxide-promoted intramolecular lactonization as the key steps.

Source: Molecules

DOI: 10.3390/molecules29235500

Authors: Jingjing Bi, Minhao Chen, Pengpeng Nie, Yuanfang Liu, Jun Liu, Yuguo Du