Year: 2024
Type: article
Study design: Observational Study
Abstract: Introduction: Antibiotic exposures in early life may affect weight by altering the gut microbiota, potentially increasing the likelihood of early pubertal maturation.Objective: To examine whether repeated antibiotic exposure by age eight is associated with early pubertal maturation. Design, Setting, and Participants:This research is a retrospective study involving 122 children.There were sixty-nine cases with early pubertal development (pubertal group), in which fourteen cases (20%) were started with leuprolide acetate.There were fifty-three cases without pubertal development (control group).The antibiotics prescriptions were evaluated retrospectively in both groups using electronic health records.The first age antibiotic prescription, the type of antibiotics, and the total number of antibiotic prescriptions were recorded.Results: There were no significant differences between the groups regarding the first-age antibiotic prescription, the type of antibiotics, and the total number of antibiotic prescriptions.There was no correlation between the number of antibiotics prescriptions, the first-age antibiotic prescription, and levels of LH, FSH, E2, and the difference between bone age and chronological age. Conclusion:Although environmental antibiotic exposure may trigger precocious.puberty, the use of antibiotics prescribed for treatment may not affect precocious puberty.
Authors: Kayseri City Training, Pediatric Endocrinology Kayseri
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4404599611