Immunogenicities of vaccines including the immunoglobulin M-degrading enzyme of Streptococcus suis, rIde , and protective efficacy against serotype 14 in piglets
Year: 2024
Type: article
Abstract: Streptococcus suis ( S. suis ) is a major porcine pathogen. Some strains have a substantial zoonotic potential such as serotype ( cps ) 14 as the second most important cps in human infections. To this date no licensed S. suis vaccine is available in Europe though subunit vaccines and bacterins have been examined by several scientific groups worldwide. Objectives of this study were to determine protective efficacy of rIde Ssuis vaccination against intranasal S. suis cps 14 challenge in conventional weaned piglets and to investigate additionally immunogenicity of rIde Ssuis vaccination in cesarean-derived colostrum-deprived (CDCD) piglets. Immunization led to reduction of bacterial multiplicity in porcine blood and delayed onset of clinical signs of cps 14 disease in conventional rIde Ssuis -vaccinated piglets. However, significant differences were not recorded which might be related to comparable low anti-Ide Ssuis antibody levels and insufficient neutralization of IgM protease activity in this animal experiment. In contrast, immunization of cesarean-derived colostrum-deprived piglets with rIde Ssuis resulted in high α-rIde Ssuis IgG antibody levels and a highly significant reduction of the survival factor of the cps 14 challenge strain in porcine blood in vitro . In conclusion, the results of this study indicate bactericidal immunity against S. suis cps 14 by Ide Ssuis specific immunity.
Source: Vaccine X
Authors: L. Mayer, C. Liedel, K. Klose, A. de Greeff, K. Rieckmann, C.G. Baums
Institutions: Leipzig University, Wageningen University & Research
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,560
OpenAlex ID: W4404600075