Fixation alters the physical properties of tumor tissue that regulate nanomedicine transport
Year: 2024
Type: article
Abstract: To have the desired therapeutic effect, nanomedicines and macromolecular medications must move from the site of injection to the site of action, without having adverse effects. Transvascular transport is a critical step of this navigation, as exemplified by the Enhanced Permeability and Retention (EPR) effect in solid tumors, not found in normal organs. Numerous studies have concluded that passive, diffusion- and convection-based transport predominates over active, cellular mechanisms in this effect. However, recent work using a new approach reevaluated this principle by comparing tumors with or without fixation and concluded the opposite. Here, we address the controversy generated by this new approach by reporting evidence from experimental investigations and computer simulations that separate the contributions of active and passive transport. Our findings indicate that tissue fixation reduces passive transport as well as active transport, indicating the need for new methods to distinguish the relative contributions of passive and active transport.
Source: Drug Delivery
Institutions: Materia (United States), University of Cyprus, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology, Tufts University, Carnegie Mellon University, University of Connecticut, University of California, San Francisco, UCSF Helen Diller Family Comprehensive Cancer Center, Duke University, Harvard University, Massachusetts General Hospital
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,864
Funders: National Foundation for Cancer Research, Advanced Medical Research Foundation, National Institutes of Health, Ludwig Center at Harvard, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of General Medical Sciences, HORIZON EUROPE European Research Council
Awards: G1220810649, G1402646273, G149958803, G1586690412, G220981983, G2273832452, G2669297942, G2676724552, G3513290447, G4255607378, G4516272527, G5045559378, G5252742216, G5561814528, G7277439466, G7357122397, G7362815187, Dissecting Pediatric Brain Tumor Microenvironment to Improve Treatment, G8139384391, G8340145482, Reengineering obesity-induced abnormal microenvironment to improve PDAC treatment, Reprogramming the tumormicroenvironment to improve immunotherapy of glioblastoma, Improving treatment of HER2+ breast cancer brain metastasis by targeting lipid metabolism, Chemically Assisted Electrotransfer of DNA
OpenAlex ID: W4404603928