Synthesis of 2,4,5-vinylic-trisubstituted oxazoles via a Palladium-catalyzed cascade coupling reaction
Year: 2024
Type: article
Abstract: A novel one-step synthesis of valuable 2,4,5-vinylic-trisubstituted oxazoles is described. This reaction, utilizing readily available β,β-dibrominated secondary enamides and terminal alkenes as starting materials, occurs via a ligand-free Palladium-catalyzed cascade intramolecular C O coupling/intermolecular Heck reaction .
Source: Tetrahedron Letters
Authors: Jun Ma, Huali Wang, Qingyu Meng, Haoyue Wang, Fangyi Li, Zheng Li
Institution: Tianjin University of Traditional Chinese Medicine
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $3,690
OpenAlex ID: W4404604085