Plasmalogens Improve Lymphatic Clearance of Amyloid Beta from Mouse Brain and Cognitive Functions
Year: 2024
Type: article
Abstract: Amyloid beta (Aβ) is a neuronal metabolic product that plays an important role in maintaining brain homeostasis. Normally, intensive brain Aβ formation is accompanied by its effective lymphatic removal. However, the excessive accumulation of brain Aβ is observed with age and during the development of Alzheimer's disease (AD) leading to cognitive impairment and memory deficits. There is emerging evidence that plasmalogens (Pls), as one of the key brain lipids, may be beneficial for AD and cognitive aging. Here, we studied the effects of Pls on cognitive functions and the lymphatic clearance of Aβ from the brain of AD mice and mice of different ages. The results showed that Pls effectively reduce brain Aβ levels and facilitate learning in aged but not old mice. In AD mice, Pls improve the lymphatic clearance of Aβ that is accompanied by an increase in general motor activity and an improvement of the emotional status and learning ability. Thus, these findings suggest that Pls could be a promising candidate for the alternative or concomitant therapy of AD and age-related brain diseases to enhance the lymphatic clearance of Aβ from the brain and cognitive functions.
Authors: Alexander Shirokov, Daria Zlatogosrkaya, Viktoria Adushkina, Elena Vodovozova, Kristina Kardashevskaya, Ruslan Sultanov, Sergey Kasyanov, Inna Blokhina, Andrey Terskov, Maria Tzoy, Arina Evsyukova, Alexander Dubrovsky, Matvey Tuzhilkin, Inna Elezarova, Alexander Dmitrenko, Maria Manzhaeva, Valeria Krupnova, Anastasiia Semiachkina-Glushkovskaia, Egor Ilyukov, Dmitry Myagkov, Dmitry Tuktarov, Sergey Popov, Tymophey Inozemzev, Nikita Navolokin, Ivan Fedosov, Oxana Semyachkina-Glushkovskaya
Institutions: Saratov State University, Russian Academy of Sciences, Institute of Biochemistry and Physiology of Plants and Microorganisms, Institute of Bioorganic Chemistry, A.V. Zhirmunsky National Scientific Center of Marine Biology Far Eastern Branch of the Russian Academy of Sciences, Saratov State Medical University
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,296
Funder: Russian Science Foundation
Award: G785604369
OpenAlex ID: W4404611504