The Impact of MiRNA on the Molecular Mechanisms of Invasion and Metastasis in Pancreatic Cancer
Year: 2024
Type: article
Abstract: Pancreatic cancer is a highly malignant tumor with a poor prognosis. Due to its highly invasive and metastatic characteristics, its five-year survival rate is extremely low. miRNA is a class of non-coding single-stranded RNA molecules with a length of about 20-24 nucleotides encoded by endogenous genes. A large number of studies have shown that miRNA is involved in various regulatory modes such as post-transcriptional gene expression regulation in the process of pancreatic cancer development, metastasis and invasion. MiRNA dysregulation is often observed in cancer, leading to disease progression. More and more studies have revealed specific changes in miRNA expression patterns and how they lead to the development of pancreatic cancer. This article summarizes the current research progress of miRNA in pancreatic cancer invasion and metastasis, providing a theoretical basis and new targets for the early diagnosis and treatment of pancreatic cancer.
DOI: 10.54097/bt64ec29
Authors: Ketao Xiao, Dan Liu, Lin Wu, Lijin Zhao
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W4404616971