Work

Assessment of Drug Impact on Laboratory Test Results in Hospital Settings

Year: 2024

Type: conference-paper

Abstract: Patients experiencing adverse drug events (ADE) from polypharmaceutical regimens present a huge challenge to modern healthcare. While computational efforts may reduce the incidence of these ADEs, current strategies are typically non-generalizable for standard healthcare systems. To address this, we carried out a retrospective study aimed at developing a statistical approach to detect and quantify potential ADEs. The data foundation comprised of almost 2 million patients from two health regions in Denmark and their drug and laboratory data during the years 2011 to 2016. We developed a series of multistate Cox models to compute hazard ratios for changes in laboratory test results before and after drug exposure. By linking the results to data from a drug-drug interaction database, we found that the models showed potential for applications for medical safety agencies and improved efficiency for drug approval pipelines.

Source: Pacific Symposium on Biocomputing (PSB)

DOI: 10.1142/9789819807024_0026

Authors: Victorine P. Muse, Amalie D. Haue, Cristina L. Rodríguez, Alejandro A. Orozco, Jorge H. Biel, Søren Brunak

Institutions: University of Copenhagen, Novo Nordisk Foundation

Language: English

Topic: Pharmacovigilance and Adverse Drug Reactions

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Novo Nordisk, Novo Nordisk Fonden