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Deciphering the toxic effects of polystyrene nanoparticles on erythropoiesis at single-cell resolution

Year: 2024
Type: article
Abstract: Polystyrene nanoparticles pose significant toxicological risks to aquatic ecosystems, yet their impact on zebrafish (Danio rerio) embryonic development, particularly erythropoiesis, remains underexplored. This study used single-cell RNA sequencing to comprehensively evaluate the effects of polystyrene nanoparticle exposure on erythropoiesis in zebrafish embryos. In vivo validation experiments corroborated the transcriptomic findings, revealing that polystyrene nanoparticle exposure disrupted erythrocyte differentiation, as evidenced by the decrease in mature erythrocytes and concomitant increase in immature erythrocytes. Additionally, impaired heme synthesis further contributed to the diminished erythrocyte population. These findings underscore the toxic effects of polystyrene nanoparticles on hematopoietic processes, highlighting their potential to compromise organismal health in aquatic environments.
DOI: 10.24272/j.issn.2095-8137.2024.277
Authors: Jung Kwon Eun, Mi Sung Hyeon, Lee Hansong, Ahn Soyul, Kim Yejin, Rin Lee Chae, Kim Kihun, Myung Kyungjae, Kyu Kim Won, Kim Dokyoung, Jeong Sanghwa, Oh Chang-Kyu, Hak Kim Yun
Institutions: Pusan National University, Institute for Basic Science, Ulsan National Institute of Science and Technology, Yonsei University, Korea Institute of Science and Technology, Korea University of Science and Technology, Kyung Hee University, University of California San Diego
Language: English
Subfield: Pollution
Open Access status: diamond
Funders: National Research Foundation, Pusan National University, National Research Foundation of Korea, Institute for Basic Science, Ministry of Science and ICT, South Korea, Korea Research Environment Open Network
Awards: G138947319, G2235668619, G2577990535, G2655146472, G392543403, G4338546216, G5620304377
OpenAlex ID: W4404623890
FWCI: 0.97
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Cited by: 10
Related to: 10