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Management challenges in primary hyperoxaluria type 1 with end-stage kidney disease: A case report

Year: 2024

Type: article

Abstract: • PH1, required liver-kidney transplant. • Post-transplant, developed complications leading to resumed dialysis. • Stresses early detection, vigilant monitoring, and multidisciplinary care. • Early detection, diagnostics, and customized post-transplant care are crucial. • Future research should focus on improving methods, techniques, and complication management. Primary hyperoxaluria (PH) is a metabolic condition that leads to oxalate production, resulting in kidney failure and oxalate nephropathy. Posttransplant mobilization of oxalate poses a risk of recurrence. This case emphasizes the importance of measures in cases of end-stage kidney disease (ESKD) with unknown origins. A 53-year-old man with a history of hypothyroidism, recurring kidney stones, and a family background of renal disease and stomach cancer presented with high blood pressure and elevated creatinine levels (2 mg/dL). A subsequent renal biopsy confirmed PH1. Despite initiating hemodialysis, his kidney function deteriorated, necessitating a liver and kidney transplant. Following the transplant, the patient developed lymph node enlargement. Experienced humoral rejection, leading to the resumption of hemodialysis. The case discussion highlights the treatment complexities associated with PH1, emphasizing the importance of detection and vigilant monitoring post transplantation and multidisciplinary care for managing complications effectively. Early detection, thorough diagnostics, and customized posttransplant care play roles in managing hyperoxaluria. Future research should focus on enhancing methods, refining transplantation techniques, and developing strategies to prevent and manage complications effectively.

Source: Transplantation Reports

DOI: 10.1016/j.tpr.2024.100165