Work

Unveiling the versatility of the thioredoxin framework: Insights from the structural examination of Francisella tularensis DsbA1

Year: 2024

Type: article

Abstract: oxidative folding pathway. Overall, this work underscores the remarkable malleability of the TRX catalytic core, a ubiquitous and ancestral protein fold. This not only contributes to broadening the structural and functional diversity seen within proteins utilising this core fold but will also enhance the accuracy of AI-driven protein structural prediction tools.

Source: Computational and Structural Biotechnology Journal

DOI: 10.1016/j.csbj.2024.11.034

Authors: Stephanie Penning, Yaoqin Hong, Taylor Cunliffe, Lilian Hor, Makrina Totsika, Jason J. Paxman, Begoña Heras

Institutions: La Trobe University, Queensland University of Technology

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,230

Funders: Australian Nuclear Science and Technology Organisation, Australian Cancer Research Foundation, Australian Synchrotron, La Trobe University, Medical Research Council, Australian Research Council, National Health and Medical Research Council

Awards: Dissecting the pathogenic triad of enteric pathogens: Assembly, structure and function of autotransporter proteases, How bacteria form resistant aggregates and biofilms, DsbA foldases from multidrug resistant pathogens as targets for new antimicrobials, Molecular mechanisms of novel bacterial copper defense proteins, How auto-transporter proteins mediate bacterial interactions

OpenAlex ID: W4404624983

FWCI: 0.462

Cites: 93

Cited by: 4

Related to: 10