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The interaction of second trimester prenatal maternal inflammation and psychosocial stress on offspring depressive symptoms in adolescence

Year: 2024
Type: article
Abstract: Background: Higher second trimester (T2) prenatal maternal inflammation (PNMI) and prenatal maternal psychosocial stress have been shown to independently contribute to offspring depression risk. Similarly, interactions between sources of inflammation and maternal daily life stress in T2, previously have been associated with increased offspring adolescent depressive symptoms. We aimed to extend previous findings by examining the potential interaction between exposure to higher T2 PNMI and maternal daily life stress on offspring depressive symptoms in adolescence. Methods: 614 mother-offspring dyads from the Child Health and Development Studies (CHDS) had data available for T2 maternal serum interleukin (IL)-6, IL-8, IL-1 receptor antagonist (IL-1ra), and soluble TNF receptor-II (sTNF-RII), presence/absence of maternal reported daily life stress coded from interviews primarily conducted in T2, and adolescent offspring (ages 15-18 years) depressive symptoms assessed via self-report. Interactions were evaluated using hierarchical multiple regressions, controlling for maternal education. Results: associated with offspring depression in the presence of daily life stress. Maternal T2 IL-1ra and sTNF-RII were not associated with offspring adolescent depressive symptoms. Conclusion: The interaction of the adverse impacts of maternal daily life stress and higher maternal IL-6 and/or IL-8 levels during the second trimester may contribute significantly to exacerbate depression risk in adolescent offspring. These results have potential implications for multiple targets of future early intervention and prevention research.
DOI: 10.1016/j.bbii.2024.100096
Authors: Rachel H. Furlan, Madeline R. Pike, Emily Lipner, Elizabeth C. Breen, Barbara A. Cohn, Piera M. Cirillo, Nickilou Y. Krigbaum, Ann M. Kring, Thomas M. Olino, Lauren B. Alloy, Lauren M. Ellman
Language: English
Field: Medicine
Open Access status: gold
Estimated APC paid: $2,500
Funders: U.S. Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, National Institute of Child Health and Human Development, Norman Cousins Center for Psychoneuroimmunology, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G158711569, G1969890937, G3079752662, G3573580748, G3674062703, G3995374491, G4886452122, G7485967758, G8560595515, G8888098372, G9000304172, Integrated Reward-Inflammation Model of First Onset of Major Depression in Adolescence, G902838897
OpenAlex ID: W4404630267
FWCI:
Cites: 95
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Related to: 10