The impact of microbiome modulation on neutrophil levels and cardiovascular disease prevention
Year: 2024
Type: article
Abstract: Cardiovascular disease (CVD) continues to be a major worldwide health issue, mainly caused by inflammatory pathways.Neutrophils are crucial immune cells that have a significant impact on inflammation and tissue damage in the cardiovascular system.High levels of neutrophils play a key role in causing atherosclerosis, unstable plaques, and vascular damage, making high neutrophil counts a reliable indicator of higher cardiovascular disease risk.Recent research has concentrated on the gut microbiome, which is a complicated collection of microorganisms that impacts different bodily functions, such as immune regulation.Metabolites originating from the microbiome, like SCFAs and TMAO, can either enhance or reduce inflammation and have a notable effect on neutrophil activity.Although the potential for microbiome-based interventions to influence immune responses and lower the risk of CVD is impressive, numerous studies are constrained in their scope and duration, lacking a standardized method for comprehending these interactions.This review seeks to examine how changing the microbiome can affect neutrophil behavior and inflammation, highlighting the importance of ongoing clinical research and comprehensive, multi-omics methods to fully understand the benefits of using microbiome strategies for preventing and managing CVD.
Author: Sasmita Das
Institution: Utkal University
Language: English
Topic: Gut microbiota and health
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4404641427