Work

Ultrastructural alterations and mitochondrial dysfunction in skeletal muscle of peripheral artery disease patients: Implications for early therapeutic interventions

Year: 2024

Type: article

Abstract: : Peripheral artery disease (PAD) is characterized by skeletal muscle and mitochondrial dysfunction. Ultrastructural changes in skeletal muscle myofibers and mitochondria morphology can provide significant information on the PAD pathophysiology. Here, we investigated skeletal muscle and mitochondria morphological and functional changes at the sarcomere level and across the disease progression and have found that sarcomere lengths and mitochondria count and function are associated with disease progression, indicating loss of skeletal muscle contractile and metabolic function. Ultrastructural changes in the PAD skeletal muscle can provide significant information in the development of new treatments.

Source: PubMed

DOI: 10.17179/excli2024-7592