Curcumin modified Fe3O4 with efficient SDT for the treatment of breast cancer
Year: 2024
Type: article
Abstract: Sonodynamic therapy (SDT) is a non-invasive anti-tumor strategy with good efficacy, strong penetration and few side effects. However, the microenvironment of tumor hypoxia and high expression of hydrogen peroxide (H 2 O 2 ) limits the efficiency of SDT. In this work, we have prepared a ultrasound-enhanced anti-tumor material by hydrothermal method , and the nanomaterials with optimal catalytic ability are identified by controlling the quality of curcumin (Fe 3 O 4 /Cur). The Fe 3 O 4 /Cur is not only capable of generating ROS by ultrasound excitation, but also generates ROS by the Fenton reaction with H 2 O 2 , and the SDT effect of Fe 3 O 4 /Cur is further enhanced. Under ultrasound stimulation, the Fe 3 O 4 /Cur can effectively kill the breast cancer cells within 15 min. This work provides a new idea for the treatment of breast cancer.
Source: Materials Letters
Institutions: Shanxi Medical University, Shanxi Academy of Medical Sciences
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: hybrid
Estimated APC paid: $2,540
OpenAlex ID: W4404645922