Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis
Year: 2024
Type: article
Study design: Observational Study
Abstract: Lower respiratory tract infections (LRTIs) are a driving factor for lung function decline in children with cystic fibrosis (CF). The respiratory microbiota is closely related to the pathogenesis of LRTIs in healthy infants, data in CF infants is scarce. We compared nasal microbiota development between CF and healthy infants and assessed associations between early-life nasal microbiota, LRTIs and antibiotic treatment in CF infants. We analyzed the microbiota after amplification of the V3-V4 region of the 16S rRNA gene from 1511 biweekly nasal samples from 50 CF and 30 healthy infants. Microbiota diversity differed between CF infants and healthy controls following LRTIs and/or antibiotic treatment. CF infants with a lower α-diversity presented with a subsequent higher number of LRTIs. Early nasal microbiota alterations may contribute to an increased susceptibility to LRTIs in CF infants and may further increase after LRTIs and antibiotic treatment. This emphasizes the possible preventive potential of targeting the nasal microbiota in CF-related LRTI management.
Source: Communications Medicine
Authors: Ruth Steinberg, Nadja Mostacci, Elisabeth Kieninger, Bettina Frauchiger, Carmen Casaulta, Jakob Usemann, Alexander Moeller, Daniel Trachsel, Isabelle Rochat, Sylvain Blanchon, Dominik Mueller-Suter, Barbara Kern, Maura Zanolari, Urs Frey, Kathryn A. Ramsey, Markus Hilty, Philipp Latzin, Insa Korten, SCILD study group, BILD study group
Institutions: University of Bern, University Hospital of Bern, University Children’s Hospital Basel, University of Zurich, University Children's Hospital Zurich, Centre Hospitalier Universitaire Vaudois, University of Lausanne, Kantonsspital Aarau, Ospedale San Giovanni Bellinzona, Ospedale Regionale di Bellinzona e Valli, The Kids Research Institute Australia, The University of Western Australia
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,490
Awards: Impact of Early Lung Physiology, Viral Infections and Microbiome on the Development and Progression of Lung Disease in Children with Cystic Fibrosis, G5539615066, Impact of air pollution on profibrotic and autophagy related mechanisms involved in the development of the respiratory system in infants
OpenAlex ID: W4404647456