Work

Haemodynamics in Left Ventricular Remodelling using Cardiovascular Lumped-Parameter Model

Year: 2024

Type: conference-paper

Abstract: Left ventricular remodelling is one of the complications of myocardial infarction.It causes the ventricle to lose contractility and to become dilate, thus changing the cardiac haemodynamics.In this study, the haemodynamic changes in left ventricular remodelling are investigated using the cardiovascular lumped-parameter model.The model simplifies blood circulation and cardiac function using electrical components such as resistor, capacitor, inductor, and diode, which represent the vessels resistance, vessels compliance, blood inertia, and heart valve, respectively.To simulate ventricular remodelling, the active and passive elastances of the left ventricle are varied by increasing and decreasing them by 10 times than the baseline values.Decreasing the active elastance reduces LV contractility, like in the case of a heart failure.Meanwhile, increasing the passive elastance makes the LV stiffer, like in the case of ventricular hypertrophy.The model eases the analysis of left ventricular remodelling without requiring complex model but will require further validation using real patients data.

Source: Proceedings of International Exchange and Innovation Conference on Engineering & Sciences (IEICES)

DOI: 10.5109/7323347

Authors: Siti Munirah Muhammad Ali, Muhammad Fadhli Nadhil Nashron, Wan Naimah Wan Ab Naim, Mohd Jamil Mohamed Mokhtarudin, Wahbi El-Bouri

Institutions: Universiti Malaysia Pahang Al-Sultan Abdullah, University of Liverpool

Language: English

Topic: Cardiovascular Function and Risk Factors

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Kementerian Pendidikan Malaysia