Work

SLP2 and MIC13 synergistically coordinate MICOS assembly and crista junction formation

Year: 2024

Type: article

Abstract: double KO cells through YME1L depletion reinstates MIC60-subcomplex assembly and cristae morphology. Overall, we propose SLP2 and the MIC10-subcomplex act as a proteolytically controlled 'seeder' complex, facilitating MICOS-MIB complex assembly and maintaining mitochondrial integrity.

Source: iScience

DOI: 10.1016/j.isci.2024.111467

Authors: Ritam Naha, Rebecca Strohm, Yulia Schaumkessel, Jennifer Urbach, Ilka Wittig, Andreas S. Reichert, Arun Kumar Kondadi, Ruchika Anand

Institutions: Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, Goethe University Frankfurt, German Centre for Cardiovascular Research

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $3,150

Funders: Deutsche Forschungsgemeinschaft, Medizinische Fakultät, Heinrich-Heine-Universität Düsseldorf

Awards: G1424691926, G1982118090, G2419842341, G3407165798, SFB 1208: Identität und Dynamik von Membransystemen von Molekülen bis zu zellulären Funktionen, G4630431941, G7535211655

OpenAlex ID: W4404652376

FWCI: 1.627

Cites: 53

Cited by: 14

Related to: 10