Work

Evaluation of efficacy of Hemoporfin-PDT in the treatment of PWS birthmarks of young children previously received PDL treatment

Year: 2024

Type: article

Abstract: BACKGROUND: Hemoporfin-mediated photodynamic therapy (Hemoporfin-PDT) is considered a safe and effective treatment for port-wine stains (PWS). This study aims to investigate the influence of prior pulse dye laser (PDL) treatments history on the effectiveness of Hemoporfin-PDT in young children aged 1-3 years with PWS. METHODS: Data was gathered for individuals with PWS aged 1-3 years who received two or more Hemoporfin-PDT treatments. The study population was stratified into two groups: Cohort 1 (No PDL) comprised patients without a history of PDL treatment, while Cohort 2 (Prior PDL) consisted of patients with a history of PDL treatment. An analysis was conducted to investigate the relationship between treatment efficacy and variables including gender, age, location, and type of PWS. RESULTS: There were a total of 220 cases in the No PDL group and 53 cases in the Prior PDL group. It was observed that prior PDL treatment history did not impact the efficacy of Hemoporfin-PDT in treating PWS among young children. Both the type and location of PWS significantly influence the clinical effectiveness of Hemoporfin-PDT for PWS (P = 0.040, P < 0.001), while gender and age show no association with treatment outcomes (P > 0.05). Notably, the peripheral face might be an independent influencing factor for high efficacy of Hemoporfin-PDT of the facial regions (P < 0.05). CONCLUSION: Previous PDL treatment history does not impact the effectiveness of Hemoporfin-PDT therapy in young children with PWS.

Source: Photodiagnosis and Photodynamic Therapy

DOI: 10.1016/j.pdpdt.2024.104418