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Palladium‐Catalyzed Intermolecular [5+2] Cycloaddition: Highly Regioselective Synthesis of Allene‐Containing 2‐Benzoxepines

Year: 2024

Type: article

Abstract: Palladium‐catalyzed intermolecular [5+2] cycloaddition of propargylic carbonates with benzyl allenyl ethers has been developed for the synthesis of allene‐containing 2‐benzoxepines. The reaction proceeds by a pathway involving decarboxylative allenylpalladium formation, regioselective intermolecular insertion, and intramolecular nucleophilic attack. In this way, the sequential formation of C−C and C−O bonds results in the generation of a 2‐benzoxepine skeleton in a one‐pot process.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401134

Authors: Bingyu Shen, Aimei Yang, Xihong Lu, Zhijun Xin, Xuehu Li

Institutions: Chinese Academy of Sciences, Lanzhou University of Technology, Institute of Modern Physics

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

OpenAlex ID: W4404663653

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Cites: 35

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Related to: 10