Work

1,4‐Dioxane as Precursor of −CH2CH2−: A Simple and Convenient Strategy to Synthesize 1,2‐Disulfide Substituted Ethanes Initiated by Iodine

Year: 2024

Type: article

Abstract: An unprecedented I2‐initiated nucleophilic ring opening reaction of 1,4‐dioxane with thiols for the construction of various 1,2‐disulfide substituted ethanes has been developed. Previously, dihalogenated ethane, acetylene or ethylene are often used as the pre‐cursor of −CH2CH2−. Through the cleavage of two C−O bonds, 1,4‐dioxane as precursor of −CH2CH2− has been achieved for the first time. In the presence of HI, thiols could be replaced by disulfides as nucleophile. This protocol is very convenient and practical by its simple and mild conditions.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.202401143

Authors: Yufeng Liu, Wentao Xie, Zhen Wei, Lili Geng, Cengceng Du, Xiaoning Shen

Institutions: Hebei University of Engineering, Hebei North University

Language: English

Topic: Sulfur-Based Synthesis Techniques

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Hebei North University, Natural Science Foundation of Hebei Province

Award: G1906772229