Work

An elastic siderophore synthetase and rubbery substrates assemble multimeric linear and macrocyclic hydroxamic acid metal chelators

Year: 2024

Type: article

Abstract: = 2 (11) not detected). Liquid chromatography-mass spectrometry metal screening experiments detected 1 : 1 complexes of Ga(iii) or Zr(iv) and 1, 3-5, 8-10, and 12-14. Complexes of 2 : 1 stoichiometry were formed between Ga(iii) and the high-denticity, high-cavity-volume chelators 4-6, and 14. A processive intra-cavity assembly mechanism has been posited for this flexible siderophore synthetase in delivering a large set of multimeric chelators.

Source: Chemical Science

DOI: 10.1039/d4sc04888a