Anatomical, Functional, and Prognostic Results of Vitrectomy in Epiretinal Membranes Secondary to Retinal Vein Occlusions
Year: 2024
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: We investigated the anatomical and functional results of vitrectomy associated with the peeling of secondary epiretinal membranes (ERM) in patients with retinal vein occlusion (RVO) and determined the prognostic factors of surgical outcomes. METHODS: This retrospective, multicenter, observational study included 50 patients with RVO who underwent vitrectomy with ERM removal between July 2012 and February 2021. Visual acuity (VA) and central macular thickness (CMT) were investigated up to 3 years. Univariate analysis identified the predictive factors associated with functional and anatomical outcomes. RESULTS: Fifty eyes from 50 patients (62% with central RVO) were included. The mean VA of 0.9 ± 0.7 logMAR preoperatively improved to 0.5 ± 0.5 logMAR after 24 months (p = 0.01). Anatomically, the mean preoperative CMT was 501 ± 168 μm, decreasing to 348 ± 108 μm at month 24 (p = 0.008). By 36 months, VA had improved or stabilized in 90% of the eyes, whereas CMT had been reduced by at least 20% from baseline in 80% of the eyes. A lower number of intravitreal injections (IVI) were required after vitrectomy. Worse preoperative VA, absence of preoperative panretinal photocoagulation, and postoperative use of adjunctive IVI were associated with VA recovery. Higher baseline CMT and the use of preoperative dexamethasone injections were associated with an improvement in CMT. CONCLUSION: Vitrectomy for ERM secondary to RVO was effective in improving VA and recovering CMT for up to 3 years and reduced the number of IVIs. INTRODUCTION: We investigated the anatomical and functional results of vitrectomy associated with the peeling of secondary epiretinal membranes (ERM) in patients with retinal vein occlusion (RVO) and determined the prognostic factors of surgical outcomes. METHODS: This retrospective, multicenter, observational study included 50 patients with RVO who underwent vitrectomy with ERM removal between July 2012 and February 2021. Visual acuity (VA) and central macular thickness (CMT) were investigated up to 3 years. Univariate analysis identified the predictive factors associated with functional and anatomical outcomes. RESULTS: Fifty eyes from 50 patients (62% with central RVO) were included. The mean VA of 0.9 ± 0.7 logMAR preoperatively improved to 0.5 ± 0.5 logMAR after 24 months (p = 0.01). Anatomically, the mean preoperative CMT was 501 ± 168 μm, decreasing to 348 ± 108 μm at month 24 (p = 0.008). By 36 months, VA had improved or stabilized in 90% of the eyes, whereas CMT had been reduced by at least 20% from baseline in 80% of the eyes. A lower number of intravitreal injections (IVI) were required after vitrectomy. Worse preoperative VA, absence of preoperative panretinal photocoagulation, and postoperative use of adjunctive IVI were associated with VA recovery. Higher baseline CMT and the use of preoperative dexamethasone injections were associated with an improvement in CMT. CONCLUSION: Vitrectomy for ERM secondary to RVO was effective in improving VA and recovering CMT for up to 3 years and reduced the number of IVIs.
Source: Ophthalmologica
DOI: 10.1159/000542770
Institutions: Sorbonne Université, Pitié-Salpêtrière Hospital, Ajou University, Centre Hospitalier Universitaire d'Angers, National and Kapodistrian University of Athens, Centre Hospitalier Universitaire de Martinique, Centre National de la Recherche Scientifique, Institut de la Vision, Inserm, Centre hospitalier national d'ophtalmologie des Quinze-Vingts, Université Paris Cité, Hôpital Lariboisière, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Hôpital Tenon
Language: English
Topic: Retinal and Macular Surgery
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4404672163