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Adrenal epinephrine facilitates erythropoietin gene activation by hypoxia through β2 adrenergic receptor interaction with Hif-2α

Year: 2024

Type: article

Abstract: Hypobaric hypoxia activates the sympathetic nervous system (SNS) and the erythropoietin ( EPO) gene. Whether SNS activation by hypoxia influences the EPO gene activation is an unresolved question. The present study demonstrates that adrenal epinephrine facilitates hypoxia-induced EPO gene activation through the interaction of β2 adrenergic receptors (β2 ARs) with the transcriptional activator HIF-2α.

Source: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

DOI: 10.1152/ajpregu.00201.2024

Authors: Xiaoyu Su, Matthew Hildreth, Srikar Rapaka, Ying-Jie Peng, Jayasri Nanduri, Nanduri R. Prabhakar

Institution: University of Chicago

Language: English

Topic: Erythropoietin and Anemia Treatment

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute