Year: 2024
Type: article
Abstract: The 3-component Passerini reaction (3CPR), discovered little more than 100 years ago, has been demonstrated in the last few decades to be a valuable tool for accessing structural diversity and complexity, essential topics to consider in drug discovery programs. Focusing on accessing a fine-tuned family of α-acyloxyamide–oxindole hybrids, we underline herein our latest insights regarding the use of this mild reaction approach to obtain promising anticancer agents. Cheap and commercially available isatin was used as starting material. The library of α-acyloxyamide–oxindole hybrids was tested against six human solid-tumor cell lines; among them, non-small cell lung carcinoma, cervical and colon adenocarcinoma, and breast and pancreas cancer. The most potent compound displayed GI50 values in the range of 1.3–21 µM.
Source: Molecules
Language: English
Subfield: Organic Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,069
Awards: G1681786485, G2015913566, G2136739438, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos, G3644193737, G4264064983, G4616941693, Atrativas Bibliotecas de Oxindoles como Inibidores Promissores de Tirosina-Cinase para Terapia-Alvo em Cancro, G5427075073, Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos
OpenAlex ID: W4404696472