Work

Mechanism of ultrafast flavin photoreduction in the active site of flavoenzyme LSD1 histone demethylase

Year: 2024

Type: article

Abstract: by an order of magnitude, rationalizing the experimental observations. More generally, this work highlights the role of the intrinsic protein environment and details of donor-acceptor molecular configurations on the dynamics of short-range ET involving a flavin cofactor and amino acid residue(s).

Source: Chemical Science

DOI: 10.1039/d4sc06857b

Authors: Bo Zhuang, Rivo Ramodiharilafy, Alexey Aleksandrov, Ursula Liebl, Marten H. Vos