Work

Impact of glucagon-like peptide-1 receptor agonists on axonal function in diabetic peripheral neuropathy

Year: 2024

Type: article

Abstract: Diabetic peripheral neuropathy is known to be relentlessly progressive and irreversible. Prospective studies in 24 participants with diabetic peripheral neuropathy (DPN) treated with glucagon-like peptide-1 receptor agonists (GLP-1RA) demonstrated improvements in clinical neuropathy scores, nerve conduction studies, and axonal excitability recordings. Analysis of axonal excitability recordings revealed the mechanism for GLP-1RA improvement in DPN were changed consistent with improvements in Na + /K + –ATPase pump function, and this was supported by mathematical modeling.

Source: Journal of Neurophysiology

DOI: 10.1152/jn.00228.2024

Authors: Roshan Dhanapalaratnam, Tushar Issar, Ann M. Poynten, Kerry-Lee Milner, Natalie C. G. Kwai, Arun V. Krishnan

Institutions: UNSW Sydney, Prince of Wales Hospital, Prince of Wales Hospital, University of Wollongong

Language: English

Topic: Pain Mechanisms and Treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4404697131

FWCI: 2.823

Cites: 42

Cited by: 12

Related to: 10